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I think since "I" is a subject pronoun, we can say "you and I" when they are used as subjects." Me" is an object pronoun, so "you and me" are used as objects.
blunder �IS � is a verb thus me is in the predicate part of the sentence and me is an object pronoun, object pronouns are used in the predicate part but you wrote it is me ? and that is not a question the correct form should be is it me? and the answer it is I.
All the explanations above are excellent and very
clear, but actually, there are some situations when you can use both like the
"this is" case.
This is me or It�s me is used in colloquial English and is correct in
grammar since the 16th century. Although it�s much less used, �this
is I� is also correct. The same can be said for the other pronouns:
Please, I
want to talk to Kevin.
[Kevin is
speaking] This is him/This is he.
Other cases include picture caption. Both are accepted, depending on what you
wanted to say.
(this is a picture of) my friend and me.
my friend and I (are in this picture).
EDIT: Another problematic case is after "than", because the meaning may change.
She loves them more than I. (more than I do, but I love them too)
She loves them more than me. (more than she loves me)